Research Directions and Key Recent Publications

Abdominal Imaging
Fergus V. Coakley, MB, Bch, Chief

Research Directions:

• Combined MR imaging and MR spectroscopic imaging in the localization and staging of prostate cancer
• Advanced hepatic imaging, including multi-detector CT, CT cholangiography, new hepatobiliary MR contrast agents, and MR cholangiopancreatography
• Radiological evaluation of diffuse liver disease, including cirrhosis, pseudocirrhosis, and non-alcoholic hepatosis
• 3D rendering of CT and MR images, including projectional and volumetric applications and CT colonography
• Role of prenatal MRI and MRSI in fetal anomalies, fetal lung maturity, and obstetric disease
• Evaluation of prostate cancer with MR spectroscopic imaging (MRSI): a prospective multi-institutional clinicopathologic study
• The promotion of evidence-based abdominal imaging, including systematic validation or debunking of commonly held opinions or assumptions

Recent Key References:

Agarwal A, Yeh BM, Breiman RS, Qayyum A, Coakley FV. Etiology and distinguishing features of peritoneal calcification at CT. Am J Roentgenol 2004; 182:441-5.

Bae K, Fuangtharnthip P, Prasad S, Joe B, Heiken J. CT Characterization of adrenal masses using histogram analysis method. Radiology 2003; 228:735-42.

Borders RJ, Breiman RS, Yeh BM, Qayyum A, Coakley FV. Computed tomography of corpus luteal cysts. J Comput Assist Tomogr 2004; 28(3):340-2.

Bryce TJ, Yeh BM, Qayyum A, Pacharn P, Bass NM, Lu Y, Coakley FV. CT signs of hepatofugal portal venous flow in patients with cirrhosis. Am J Roentgenol 2003; 181:1629-33.

Coakley FV, Glenn OA, Qayyum A, Barkovich AJ, Goldstein R, Filly RA. Fetal MRI: A developing technique for the developing patient. Am J Roentgenol 2004; 182: 243-52.

Coakley FV, Qayyum A, Kurhanewicz J. Magnetic resonance imaging and spectroscopic imaging of prostate cancer. J Urol 2003; 170:S69-6.

Dhingsa R, Qayyum A, Coakley FV, Lu Y, Jones KD, Swanson MG, Carroll PR, Hricak H, Kurhanewicz J. Prostate cancer localization with endorectal MR imaging and MR spectroscopic imaging: effect of clinical data on reader accuracy. Radiology 2004; 230:215-220.

Elliott SP, Yeh B, Stoller M. Radiologic appreciation of a spontaneous splenorenal shunt. Urology 2004; 63(4):776-7.

Fraser ET, Coakley FV, Meng MV, Yeh BM, Joe BN, Qayyum A. Computed tomography and magnetic resonance imaging of inferior vena caval thrombus associated with metastasis to the kidney. J Comput Assist Tomogr 2004; 28:131-3.

Hong C, Pilgram TK, Zhu F, Joe BN, Towler DA, Bae KT. Improving mass measurement of coronary artery calcification using threshold correction and thin collimation in multi-detector row computed tomography: in vitro experiment. Acad Radiol 2003;10:969-77.

Joe B, Poutschi-Amin M, Woodard P. Diagnosis Please: Cor Triatriatum Dexter. Radiology 2003; 226: 701-5.

Kang HP, Scott M, Joe B, Narra V, Heiken J, Parvin C. Model for predicting the impact of gadolinium on plasma calcium measured by the o-Cresolphthalein method. Clin Chem 2004; 50:741-6.

Kroepil P, Coakley FV, Graser A, Breiman RS, Qayyum A, Yeh BM. Appearance and distinguishing features of retroperitoneal calcifications at computed tomography. J Comput Assist Tomogr 2003; 27: 860-3.

Noonan JB, Coakley FV, Qayyum A, Yeh BM, Wu L, Chen LM. MR imaging of retained products of conception. Am J Roentgenol 2003; 181:435-9.

Pickett B, Kurhanewicz J, Fein B, Coakley F, Shinohara K, Roach M. Use of magnetic resonance imaging and spectroscopy in the evaluation of external beam radiation therapy for prostate cancer. Int J Radiat Oncol Biol Phys 2003; 57:S163-64.

Visser BC, Muthusamay VR, Mulvihill SJ, Coakley F. Diagnostic imaging of cystic pancreatic neoplasms. Surg Oncol 2004; 13:27-39.

Wang ZJ, Reddy GP, Gotway MB, Yeh BM, Hetts SW, Higgins CB. CT and MR imaging of pericardial disease. Radiographics 2003; 23:S167-80.

Wang ZJ, Reddy GP, Gotway MB, Yeh BM, Higgins CB. Cardiovascular shunts: MR imaging evaluation. Radiographics 2003; 23:S181-94.

Williams G, Coakley FV, Qayyum A, Glenn OA, Breiman RS, Callen PW. Evaluation of femur length during the second and third trimesters in fetuses with myelomeningocele. Ultrasound Obstet Gynecol 2004; 23:148-51.

Yeh BM, Breiman RS, Taouli B, Qayyum A, Roberts JP, Coakley FV. Biliary tract depiction in living potential liver donors: comparison of conventional MR, Mangafodipir trisodium-enhanced excretory MR, and multi-detector row CT cholangiography--initial experience. Radiology 2004; 230(3):645-51.

Yeh BM, Coakley FV, Meng MV, Breiman RS, Stoller M. Prevalence and associations of precaval right renal arteries by multidetector CT. Radiology 2004; 230:429-33.

Yeh BM, Coakley FV, Sanchez HC, Wilson MW, Reddy GP, Gotway MB. Prevalence and appearance of azygos arch valves on contrast-enhanced CT. Radiology 2004; 230:111-5.

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Biomagnetic Imaging Laboratory
Srikantan Nagarajan, PhD, Director

Research Directions:

• Multi-modal and multi-scale imaging of functional activation and connectivity during dynamical cortical processing in audition, somesthesis and vision
• Biophysical basis of functional imaging signals (MEG, EEG, fMRI, and white-matter tractography with DTI) in auditory and somatosensory cortex
• Plasticity of cortical signal representations assayed using MEG, EEG and fMRI
• Neuroimaging of speech and language processing
• Development of novel statistical signal processing algorithms for analysis of multi-modal brain imaging data such as EEG, MEG, MRI, fMRI and DTI
• Pre-operative mapping of brain functional organization in brain tumor patients
• Localization of the source of epileptogenic activity
• Development of novel clinical applications of magnetic source imaging

Recent Key References:

Disbrow EA, Hinkley LB, Roberts TP. Ipsilateral representation of oral structures in human anterior parietal somatosensory cortex and integration of inputs across the midline. J Comp Neurol 2003; 467(4):487-95.

Henry RG, Berman JI, Nagarajan SS, Mukherjee P, Berger MS. Subcortical pathways serving cortical language sites: initial experience with diffusion tensor imaging fiber tracking combined with intraoperative language mapping. Neuroimage 2004; 21(2):616-22.

Krubitzer L, Huffman KJ, Disbrow E, Recanzone G. Organization of area 3a in macaque monkeys: contributions to the cortical phenotype. J Comp Neurol 2004; 471(1):97-111.

Sekihara K, Nagarajan SS, Poeppel D, Marantz A. Performance of an MEG adaptive-beamformer source reconstruction technique in the presence of additive low-rank interference. IEEE Trans Biomed Eng 2004; 51(1):90-9.

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Breast Imaging
Edward A. Sickles, MD, Chief

Research Directions:

• Digital mammography and outcomes analysis of the Breast Imaging Section's extensive clinical mammography experience
• Contrast-enhanced digital subtraction mammography as a novel tool in breast cancer detection

Recent Key References:

Beam CA, Conant EF, Sickles EA, Weinstein SP. Evaluation of proscriptive health care policy implementation in screening mammography. Radiology 2003; 229:534-40.

Burnside ES, Rubin DL, Shachter RD, Sohlich RE, Sickles EA. A probabilistic expert system that provides automated mammographic-histologic correlation: initial experience. Am J Roentgenol 2004; 182:481-8.

D'Orsi CJ, Bassett LW, Berg WA, Feig SA, Jackson VP, Kopans DB, Linver MN, Mendelson EB, Moss LJ, Sickles EA. Breast Imaging and Reporting Data System - Mammography. 4th ed. Reston, VA: American College of Radiology, 2003.

Ikeda DM, Birdwell RL, O'Shaughnessy KF, Brenner RJ, Sickles EA. Missed mammographic abnormalities, malpractice, and expert witnesses: does majority rule in the courtroom? Letter to the editor (reply). Radiology 2003; 229:289.

Ikeda DM, Birdwell RL, O'Shaughnessy KF, Sickles EA, Brenner RJ. Computer-aided detection output on 172 subtle findings on normal mammograms previously obtained in women with breast cancer detected at follow-up screening mammography. Radiology 2004; 230:811-9.

Kerlikowske K, Smith-Bindman R, Sickles EA. Short-interval follow-up mammography: are we doing the right thing? Editorial. J Natl Cancer Inst 2003; 95:418-9.

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Center for Molecular and Functional Imaging
Ronald L. Arenson, MD, Acting Director

Research Directions:

• Characterization of prostate cancer using in vivo MRI, DCE MRI, DTI and MRSI, and ex vivo tissue analysis using micro-array analysis, immunohistochemistry and high resolution MRS
• The cost-effective use of multiple diagnostic information, statistical methods for medical diagnosis, imaging clinical trials, osteoporosis, and cancer clinical trials
• Assessment of heart-brain interaction using high resolution scintigraphic techniques in models of sudden cardiac death, neural injury, and postnatal maturation.
• Assessment of mechanisms of cell injury in models of myocardial infarction and contrast induced nephropathy, and exploration of strategies for cell protection such as hypothermia and preconditioning
• Assessment of ventricular remodeling following experimental myocardial infarction using radionuclide ventriculography
• Development of novel high field MR morphological and metabolic imaging techniques for the study of cancer and brain disorders using a 3T MR scanner
• Diffusion tensor imaging of the brain and spine
• MRI and MR spectroscopic imaging of prostate cancer
• Quantitative X-ray absorptiometry
• Electrical impedance tomography to measure subregional body composition

Recent Key References:

Berman JI, Berger MS, Mukherjee P, Henry RG. Diffusion-tensor imaging-guided tracking of fibers of the pyramidal tract combined with intraoperative cortical stimulation mapping in patients with gliomas. J Neurosurg 2004; 101(1):66-72.

Cunningham CH, Vigneron DB, Chen AP, Xu D, Hurd RE, Sailasuta N, Pauly JM. Design of symmetric-sweep spectral-spatial RF pulses for spectral editing. Magn Reson Med 2004; 52(1):147-53.

Dae M, Gao D, Ursell P, Stillson C, Sessler D. Safety and efficacy of endovascular cooling and rewarming for induction and reversal of hypothermia in human-sized pigs. Stroke 2003; 34:734-8.

Dhingsa R, Qayyum A, Coakley FV, Lu Y, Jones KD, Swanson MG, Carroll PR, Hricak H, Kurhanewicz J. Prostate cancer localization with endorectal MR imaging and MR spectroscopic imaging: effect of clinical data on reader accuracy. Radiology 2004; 230(1):215-20.

Frelinger A, Furman M, Barnard M, Krueger L, Dae M, Michelson A. Combined effects of mild hypothermia and glycoprotein IIb/IIIa antagonists on platelet-platelet and leukocyte-platelet aggregation. Am J Cardiol 2003; 92:1099-101.

Graves EE, Pirzkall A, McKnight TR, Vigneron DB, Larson DA, Verhey LJ, McDermott M, Chang S, Nelson SJ. Use of proton magnetic resonance spectroscopic imaging data for planning focal radiation therapies. Image Analysis & Stereology 2004; 21:69-76.

Hale S, Dae M, Kloner R. Hypothermia during reperfusion limits 'no relow' injury in a rabbit model of acute myocardial infarction. Cardiovasc Res 2003; 59:715-22.

Henry RG, Berman JI, Nagarajan SS, Mukherjee P, Berger MS. Subcortical pathways serving cortical language sites: initial experience with diffusion tensor imaging fiber tracking combined with intraoperative language mapping. Neuroimage 2004; 21(2):616-22.

Henry RG, Oh J, Nelson SJ, Pelletier D. Directional diffusion in relapsing-remitting multiple sclerosis: A possible in vivo signature of Wallerian degeneration. J Magn Reson Imaging 2003; 18(4):420-6.

Hurd R, Sailasuta N, Srinivasan R, Vigneron D, Pelletier D, Nelson S. Measurement of brain glutamate using TE-averaged PRESS at 3T. Magn Reson Med 2004; 51(3):435-40.

Lee M, Pirzkall A, Akazawa P, Verhey LJ, Nelson SJ. MR spectroscopy of radiation effects in healthy brain tissue following radiotherapy. Int J Radiat Oncol Biol Phys 2003; 57(S):133-4.

Lee MC, Pirzkall A, McKnight T, Nelson SJ, 1H-MRSI of radiation effects in normal-appearing white matter: dose-dependence and impact on automated spectral classification. J Magn Reson Imag 2004; 19(4):379-88.

Li X, Jin H, Lu Y, Oh J, Chang S, Nelson SJ. Identification of MRI and 1H MRSI parameters that may predict survival for patients with malignant gliomas. NMR Biomed 2004; 17(1): 10-20.

Lu, Y, Fang JQ (eds). Advanced Medical Statistics. Singapore, World Scientific Publications, Co., 2003.

Lu Y, Jin H, Genant HK. On the equivalence of two diagnostic tests based on paired observations. Stat Med 2003; 22(10):3029-44.

Maas LC, Mukherjee P, Carballido-Gamio J, Veeraraghavan S, Miller SP, Partridge SC, Henry RG, Barkovich AJ, Vigneron DB. Early laminar organization of the human cerebrum demonstrated with diffusion tensor imaging in extremely premature infants. Neuroimage 2004; 22(3):1134-40.

Miller SP, McQuillen PS, Vigneron DB, Glidden DV, Barkovich AJ, Ferriero DM, Hamrick SE, Azakie A, Karl TR. Preoperative brain injury in newborns with transposition of the great arteries. Ann Thorac Surg 2004; 77(5):1698-706.

Mohr DC, Epstein L, Luks TL, Goodkin D, Cox D, Goldberg A, Chin C, Nelson SJ. Brain lesion volume and neuropsychological function predict efficacy of treatment for depression in multiple sclerosis. J Consult Clin Psychol 2003; 71(6):1017-24.

Nelson SJ. Multivoxel magnetic resonance spectroscopy of brain tumors. Mol Cancer Ther 2003; 2(5):497-507.

Oh J, Henry RG, Genain C, Nelson SJ, Pelletier D. Mechanisms of normal appearing corpus callosum injury related to pericallosal T1 lesions in multiple sclerosis using directional diffusion tensor and 1H MRS imaging. J Neurol Neurosurg Psychiatry 2004; 75(9):1281-6.

Oh J, Henry RG, Pirzkall A, Lu Y, Li X, Catalaa I, Chang S, Dillon WP, Nelson SJ. Survival analysis in patients with glioblastoma multiforme: predictive value of choline to N-acetylaspartate index, apparent diffusion coefficient and relative cerebral blood volume. J Magn Reson Imag 2004; 19:546-54.

Oh J, Pelletier D, Nelson SJ. Preferential corpus callosum axonal injury in multiple sclerosis measured by proton magnetic resonance spectroscopic imaging. Arch Neurol 2004; 61:1081-6.

Partridge SC, Mukherjee P, Henry RG, Miller SP, Berman JI, Jin H, Lu Y, Glenn OA, Ferriero DM, Barkovich AJ, Vigneron DB. Diffusion tensor imaging: serial quantitation of white matter tract maturity in premature newborns. Neuroimage 2004; 22(3):1302-14.

Pickett B, Ten Haken RK, Kurhanewicz J, Qayyum A, Shinohara K, Fein B, Roach M 3rd. Time to metabolic atrophy after permanent prostate seed implantation based on magnetic resonance spectroscopic imaging. Int J Radiat Oncol Biol Phys 2004; 59(3):665-73.

Pirzkall A, Li X, Oh J, Chang S, Berger MS, McDermott MW, Larson DA, Verhey LJ, Dillon WP, Nelson SJ. 3D MR-Spectroscopy for resected high-grade gliomas prior to RT: tumor extent according to metabolic activity in relation to MRI. Int J Radiat Oncol Biol Phys 2004; 59(1):126-37.

Pouliot J, Kim Y, Lessard E, Hsu IC, Vigneron DB, Kurhanewicz J. Inverse planning for HDR prostate brachytherapy used to boost dominant intraprostatic lesions defined by magnetic resonance spectroscopy imaging. Int J Radiat Oncol Biol Phys 2004; 59(4):1196-207.

Qayyum A, Coakley FV, Lu Y, Olpin JD, Wu L, Yeh BM, Carroll PR, Kurhanewicz J. Organ-confined prostate cancer: effect of prior transrectal biopsy on endorectal MRI and MR spectroscopic imaging. AJR Am J Roentgenol 2004; 183(4):1079-83.

Schneider TE, Barland C, Alex AM, Mancianti ML, Lu Y, Cleaver JE, Lawrence HJ, Ghadially R. Measuring stem cell frequency in epidermis: A quantitative in vivo functional assay for long-term repopulating cells. Proc Natl Acad Sci U S A. 2003; 100(20):11412-17.

Srinivasan R, Vigneron D, Napapon S, Hurd R, Nelson SJ. A comparative study of myo-inositol quantification using LCmodel at 1.5 T and 3.0 T with 3D 1H proton spectroscopic imaging of the human brain. Magn Reson Imaging 2004; 22(4):523-8.

Swanson MG, Vigneron DB, Tabatabai ZL, Males RG, Schmitt L, Carroll PR, James JK, Hurd RE, Kurhanewicz J. Proton HR-MAS spectroscopy and quantitative pathologic analysis of MRI/3D-MRSI-targeted postsurgical prostate tissues. Magn Reson Med 2003; 50(5):944-54.

Wu M, Gao D, Sievers R, Lee R, Hasegawa B. Pinhole single-photon emission computed tomography for myocardial perfusion imaging of mice. J Am Coll Card 2003; 42:576-82.

Xu D, Henry RG, Mukherjee P, Carvajal L, Miller SP, Barkovich AJ, Vigneron DB. Single-shot fast spin-echo diffusion tensor imaging of the brain and spine with head and phased array coils at 1.5 T and 3.0 T. Magn Reson Imaging 2004; 22(6):751-9.

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Research Directions:

• Development of new MRI and CT contrast media
• Characterize disease by changes in function and microvasculature
• Development of new UCSF optical imaging unit
• Breast cancer characterizations with molecular imaging

Recent Key References:

Daldrup-Link H, Brasch RC. Macromolecular contrast agents for MR mammography: current status. Eur Radiol 2003; 13:354-6.

Daldrup-Link HE, Kaiser A, Helbich T, Werner M, Bjornerud A, Link TM, Rummeny EJ. Macromolecular contrast medium (feruglose) versus small molecular contrast medium (gadopentetate) enhanced magnetic resonance imaging: differentiation of benign and malignant breast lesions. Acad Radiol 2003; 10(11):1237-46.

Daldrup-Link HE, Okuhata Y, Wolfe A, Srivastav S, Oie S, Ferrara N, Cohen RL, Shames DM, Brasch R. Decrease in tumor apparent permeability-surface area product to a MRI macromolecular contrast medium following angiogenesis inhibition with correlations to cytotoxic drug accumulation. Microcirculation 2004; 11:387-396.

Daldrup-Link HE, Rudelius M, Oostendorp RAJ, Settles M, Piontek G, Metz S, Heinzmann U, Rummeny EJ, Schlegel J, Link TM. Targeting of hematopoietic progenitor cells with MR contrast agents. Radiology 2003; 228:760-7.

Daldrup-Link HE, Rydland J, Helbich T, Turetschek K, Haraldseth O, Link TM, Brasch RC, Shames D, Rummeny EJ. Quantitative MRI-estimates of breast tumor microvascular permeabilities to the macromolecular contrast agent Feruglose (Clariscan) correlate with histologic tumor grade: initial phase II multicenter trial. Radiology 2003; 229(3):885-92.

Wiart, M, Fournier LS, Novikov VY, Shames DM, Roberts TPL, Fu Y, Shalinsky DR, Brasch RC. Magnetic resonance imaging detects early changes in tumor microvascular permeability of xenograft tumors after treatment with the matrix metalloprotease inhibitor prinomastat. Technol Cancer Res Treat 2004; 3(4):377-82.

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Chest/Cardiac Imaging
W. Richard Webb, MD, Chief

Research Directions:

• High-resolution CT diagnosis of lung disease
• Utility of dynamic expiratory spiral CT
• Clinical outcomes following negative CT for acute pulmonary embolism
• Predictors of poor outcome in patients with acute PE diagnosed by spiral CT
• Quantitative assessment of function in congenital heart disease
• Characterization of myocardial ischemic injury by contrast-enhanced MRI
• Measurement of coronary blood flow and coronary flow reserve using MRI
• Development of the concept of endovascular therapy using MRI guidance

Recent Key References:

Araoz PA, Gotway MB, Trowbridge RL, Bailey RA, Auerbach AD, Higgins CB. Helical CT pulmonary angiography predictors of in-hospital morbidity and mortality in patients with acute pulmonary embolism. J Thorac Imag 2003; 18(4):207-216.

Araoz PA, Reddy GP, Tarnoff H, Roge CL, Higgins CB. MR findings of collateral circulation are more accurate measures of hemodynamic significance than arm-leg blood pressure gradient after repair of coarctation of the aorta. J Magn Reson Imaging 2003; 17(2):177-83.

Higgins CB. Modern imaging of the acute aortic syndrome. Am J Med 2004; 116(2):134.

Higgins CB, de Roos A: Cardiovascular MRI and MRA. Lippincott Williams Wilkins, Philadelphia, PA, 2004.

Kuehne T, Saeed M, Higgins CB, Gleason K, Krombach GA, Weber OM, Martin AJ, Turner D, Teitel D, Moore P. Endovascular stents in pulmonary valve and artery in swine: feasibility study of MR imaging-Guided deployment and postinterventional assessment. Radiology 2003; 226(2):475-81.

Lund GK, Watzinger N, Saeed M, Reddy GP, Yang M, Araoz PA, Curatola D, Bedigian M, Higgins CB. Chronic heart failure: global left ventricular perfusion and coronary flow reserve with velocity-encoded cine MR imaging: initial results. Radiology 2003; 227(1):209-15.

Pujadas S, Reddy GP, Lee JJ, Higgins CB. Magnetic resonance imaging in ischemic heart disease. Semin Roentgenol 2003; 38(4):320-9.

Reddy GP, Higgins CB. Magnetic resonance imaging of congenital heart disease: evaluation of morphology and function. Semin Roentgenol 2003; 38(4):342-51.

Wang ZJ, Reddy GP, Gotway MB, Higgins CB, Jablons DM, Ramaswamy M, Hawkins RA, Webb WR. Malignant pleural mesothelioma: evaluation with CT, MR imaging, and PET. Radiographics 2004; 24:105-19.

Wang ZJ, Reddy GP, Gotway MB, Yeh BM, Hetts SW, Higgins CB. CT and MR imaging of pericardial disease. Radiographics 2003; 23:S167-180.

Wang ZJ, Reddy GP, Gotway MB, Yeh BM, Higgins CB. Cardiovascular shunts; MR imaging evaluation. Radiographics 2003; 23:S181-S194.

Webb WR, Higgins CB: Thoracic Imaging: Pulmonary and Cardiovascular Radiology. Lippincott Williams Wilkins, Philadelphia, PA, 2004.

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Dynamic Neuroimaging Laboratory
Gregory V. Simpson, PhD, Director

Research Directions:

• Multimodal neuroimaging: integrating electroencephalography (EEG), magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI) to study:
  1. Perception, attention and working memory
  2. Clinical populations with disorders of attention and working memory (e.g. aging, dementia, schizophrenia).
• Animal models of neurophysiology underlying EEG/MEG
• Development of methods for EEG/MEG brain source imaging
• Investigation of the neurophysiological bases of EEG/MEG and fMRI
• Development of methods for simultaneous EEG and fMRI measurement
• Dynamic analyses of EEG, MEG
• Computational modeling of large scale spatial-temporal neural networks
• Pathophysiology of stroke
• Neuroinformatics: development of probabilistic atlases of human brain anatomy and function

Recent Key References:

Ahlfors SP and Simpson GV. Geometric interpretation of fMRI-Guided MEG/EEG inverse estimates. Neuroimage 2004; 22(1):323-32.

Hwa RC, Ferree TC. Stroke detection based on the scaling properties of human EEG. Physica A 2004; 338:246-54.

Hwa RC, He W, Ferree TC. The global effects of stroke on the human electroencephalogram. J Integr Neurosci 2003; 2(1): 45-53.

Luks, TL, Simpson, GV. Preparatory deployment of attention to motion activates higher order motion processing brain regions. Neuroimage 2004; 22 (4):1515-22.

Rainer G, Lee H, Simpson GV, Logothetis NK. Working-memory related theta (4-7 Hz) frequency oscillations observed in monkey extrastriate visual cortex. Neurocomputing 2004; 58-60:965-969.

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Earl Miller Laboratory
Michael F. Wendland, PhD, Director

Research Directions:

• MRI contrast media distribution kinetics in rodent tumor models for evaluation of vascular permeability parameters and response to therapies
• Monitoring of receptor-targeted particulate drug delivery vehicles in rodent tumor models (labeled cells, liposomes, nanoparticulates) with MRI
• MRI of traumatic brain injury in rodents
• Evaluation of brain ischemia in neonatal rodents using MRI (model for birth-related brain ischemia)
• MRI of experimental allergic encephalomyelitis (multiple sclerosis model) in common marmoset
• Study of rheumatoid arthritis models in rodents using MRI.
• MRI of myocardial ischemic injuries; contrast-based assessment of viability, edema, and dysfunction

Recent Key References:

Kuehne T, Saeed M, Gleason K, Turner D, Teitel D, Higgins CB, Moore P. Effects of pulmonary insufficiency on biventricular function in the developing heart of growing swine. Circulation 2003; 108:2007-13.

Krombach GA, Baireuther R, Higgins CB, Saeed M. Distribution of intramyocardially injected extracellular MR contrast medium: effects of concentration and volume. Eur Radiol 2004; 14:334-40.

Krombach GA, Saeed M, Higgins CB, Novikov V, Wendland MF. Contrast-enhanced MR delineation of stunned myocardium with administration of MnC12 in Rats. Radiology 2004; 230(1):183-90.

Lund GK, Stork A, Saeed M, Bansmann MP, Gerken JH, Muller V, Mester J, Higgins CB, Adam G, Meinertz T. Acute myocardial infarction: evaluation with first-pass enhancement and delayed enhancement with MR imaging compared with 201ST1 SPECT imaging. Radiology 2004; 232:49-57.

Schalla S, Wendland MF, Higgins CB, Ebert W, Saeed M. Accentuation of high susceptibility of hypertrophied myocardium to ischemia: Gadophrin-enhanced and cardiac function assessment using magnetic resonance imaging. Magn Reson Med 2004; 51:552-8.

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Interventional Magnetic Resonance Imaging
Charles B. Higgins, MD and David A. Saloner, PhD, Co-Directors

Research Directions:

• Evaluation of benefit added by using MRI in combination with an interventional angiography suite
• Development of real-time MRI methods for guiding interventions in the MRI scanner
• Assessing the use of MR-determined hemodynamic measures for monitoring interventional procedures such as stenting or angioplasty
• Determination of changes in end-organ perfusion in response to interventional procedures
• Development of methods for site-specific delivery of therapeutic agents
• Development of MR guided cardiac catheterization
• Use of MR fluoroscopy for guidance of transcatheter interventions for adult and congenital heart disease

Recent Key References:

Kuehne T, Saeed M, Higgins, Gleason K, Krombach GA, Weber O, Martin A, Turner D, Teitel D, Moore P. MRI guided deployment and postinterventional assessment of endovascular stents in the pulmonary position in swine. Radiology 2003; 226:475-81.

Martin AJ, Weber OM, Saeed M, Roberts TPL. Steady state imaging for visualization of endovascular interventions. Magn Reson Med 2003; 50(2):434-38.

Pujadas S, Reddy GP, Weber O, Lee JJ, Higgins CB. MR imaging assessment of cardiac function. J Magn Reson Imaging 2004: 19:789-99.

Saeed M, Lee R, Martin A, Weber OM, Krombach GA, Schalla S, Lee M, Saloner D, Higgins CB. Transendocardial delivery of extracellular tracers using a combination of x-ray and MRI fluoroscopy (XMR)-guidance: feasibility study in dogs. Radiology 2004; 231:689-96.

Schalla S, Saeed M, Higgins CB, Martin A, Weber OM, Moore P. Magnetic resonance imaging-guided cardiac catheterization in swine model of atrial septal defect. Circulation 2003; 108:1865-70.

Weber OM, Martin AJ, Higgins CB. Whole heart steady state free precession coronary artery magnetic resonance angiography. Magn Reson Med 2003; 50:1223-8.

Weber OM, Schalla S, Martin AJ, Lee R, Saeed M, Shunk KA, Moore P, Higgins CB. Interventional cardiac magnetic resonance imaging. Sem Roentgenol 2003; 38, 352-7.

Wilson MW, Fidelman N, Weber OM, Martin AJ, Gordon RL, Kerlan R, LaBerge HM, Saeed M. Experimental renal artery embolization in a combined MR imaging/angiographic unit. J Vasc Interv Radiol 2003; 14:1169-75.

Wilson MW, Kerlan RK Jr., Fidelman N, LaBerge JM, Venook AM, Gordon RL. Regional hepatocellular carcinoma therapy with a magnetically targeted chemotherapy carrier in a dual MRI / X-ray angiography system - initial experience with 4 patients. Radiology 2004; 230(1):287-93.

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Interventional Radiology
Roy L. Gordon, MD, Chief

Research Directions:

• Interventional MR projects based on the new combined MR/Fluoroscopy suite: work on embolization, MR compatible wires, balloons and stents
• Joint project with Transplant service for inplantation of pancreatic islet cells
• Use of expandable metallic stents in the airways
• Joint project with Vascular Surgery in treating high-risk aortic arterial aneurysms with endovascular stent-grafts
• Magnetic catheter navigation in the 1.5 Tesla MRI environment

Recent Key References:

Chuter TA, Pak LK, Gordon RL, Reilly LM, Messina LM. Heparin-induced thrombocytopenia and graft thrombosis following endovascular aneurysm repair. J Endovasc Ther 2003; 10(6):1087-90.

Kerlan RK Jr, Coffey JO, Milkman MS, LaBerge JM, Wilson MW, Cea Wolanske KA, Gordon RL. Massive vaginal hemorrhage after uterine fibroid embolization. J Vasc Interv Radiol 2003; 14(11):1465-7.

LaBerge JM, Kerlan RK. Liver infarction following TIPS with a PTFE-covered stent: is the covering the cause? Hepatology 2003; 38(3):778-9; author reply 779.

Norton JA, Kerlan RK. Hepatic artery embolization for treatment of patients with metastatic carcinoid tumors: a commentary. Cancer J 2003; 9(4):241-3.

Rivera-Sanfeliz GM, Assar OS, LaBerge JM, Wilson MW, Gordon RL, Ring EJ, Kerlan RK Jr. Incidence of important hemobilia following transhepatic biliary drainage: left-sided versus right-sided approaches. Cardiovasc Intervent Radiol 2004; 27(2):137-9.

Schneider DB, Curry TK, Eichler CM, Messina LM, Gordon RL, Kerlan RK. Percutaneous mechanical thrombectomy for the management of venous thoracic outlet syndrome. J Endovasc Ther 2003; 10(2):336-40.

Wolanske KA, Gordon RL, Wilson MW, Kerlan RK Jr, LaBerge JM, Jacoby AF. Coil embolization of a tuboovarian anastomosis before uterine artery embolization to prevent nontarget particle embolization of the ovary. J Vasc Interv Radiol 2003; 14(10):1333-8.

Yilmaz LP, Abraham CZ, Reilly LM, Gordon RL, Schneider DB, Messina LM, Chuter TA. Is cross-femoral bypass grafting a disadvantage of aortomonoiliac endovascular aortic aneurysm repair? J Vasc Surg 2003; 38(4):753-7.

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Laboratory for Radiological Informatics
Robert G. Gould, ScD, Acting Director

Research Directions:

• Digital radiography
• Tele-imaging
• Computer-aided diagnosis (CAD) in the PACS environment

Recent Key References:

LaBerge JM, Andriole KP. Digital image processing: a primer for JVIR authors and readers: part 1: the fundamentals. J Vasc Interv Radiol 2003; 14(10):1223-30.

LaBerge JM, Andriole KP. Digital image processing: a primer for JVIR authors and readers: part 2: digital image acquisition. J Vasc Interv Radiol 2003; 14(11):1365-72.

LaBerge JM, Andriole KP. Digital image processing: a primer for JVIR authors and readers: Part 3: Digital image editing. J Vasc Interv Radiol 2003; 14(12):1481-7.

Tellis WM, Andriole KP. Implementing a MIRC query interface for a database driven teaching file. J Digit Imaging 2003; 16(2):180-4.

Tellis WM, Andriole KP. Integrating multiple clinical information systems using the Java Message Service framework. J Digit Imaging 2004; 17(2):80-6.

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Magnetic Resonance Science Center
Nola M. Hylton, PhD, Director

Research Directions:

• Applying novel MR spectroscopic and diffusion tensor imaging techniques for the study of the human newborn brain in preterm and term neonates
• Correlative MR imaging and diffuse optical spectroscopy of the breast for assessment of tumor response to chemotherapy
• Study of breast tissue composition using MRI and diffuse optical spectroscopy to assess breast cancer risk and measure risk reduction
• MRI/MRSI and histology of low grade gliomas
• Metabolic imaging of the prostate using 3DMRSI
• MRI evaluation of knee biomechanics
• Quantification of hepatic steatosis using MRI and MRS
• Optimization of MR techniques for quantification of disease burden in patients with Multiple Sclerosis
• Neurological predictors of Huntington's Disease
• In vivo MRI/MRS to study drug response in patients with relapsing-remitting multiple sclerosis
• Convection-enhanced delivery of gadolinium-containing liposomes for real time imaging during intracranial administration of liposomes
• Functional MRI study of attention: Flanner Task-fMRI and electroencelphalography of cognitive processes in healthy volunteers

Recent Key References:

Hylton NM. Evaluation of gadobenate dimeglumine for contrast-enhanced MRI of the breast. AJR Am J Roentgenol 2003; 181(3):677-8.

Ikeda DM, Hylton NM, Kuhl CK, Weinreb JC, Morris EM, Kinkel K, Hochman MG, Kaiser WA, Lewin J, Degani H, Veihweg P, Schnall MD. American College of Radiology (ACR). ACR BI-RADS - Magnetic Resonance Imaging, First Edition. In: ACR Breast Imaging and Reporting and Data System, Breast Imaging Atlas. Reston, VA American College of Radiology; 2003.

Maas LC, Mukherjee P, Carballido-Gamio J, Veeraraghavan S, Miller SP, Partridge SC, Henry RG, Barkovich AJ, Vigneron DB. Early laminar organization of the human cerebrum demonstrated with diffusion tensor imaging in extremely premature infants. Neuroimage 2004; 22(3):1134-40.

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Musculoskeletal and Quantitative Imaging Research
Sharmila Majumdar, PhD, Director

Research Directions:

• High field and high resolution magnetic resonance imaging for quantitative characterization of the morphology and function of the musculoskeletal system, with particular attention to bone, cartilage and inter-vertebral disc, and diseases such as osteoporosis, spinal disorders, and osteo-arthritis.
• Microscopic characterization of bone, cartilage, disc and other tissues using methodologies such as µ computed tomography, Fourier Transform Infra-red imaging, high resolution NMR spectroscopy, and confocal laser microscopy
• Development of high resolution, and quantitative Computed Tomography for characterizing bone geometry, micro-architecture and density, aimed at understanding aging, ethnic differences in the skeleton, osteoporosis, orthopedic implants
• Development of x-ray based methodologies for soft tissue density assessment and body composition assessment
• Electrical Impedance Tomography for the selection of soft tissue tumors and cancer risk assessment

Recent Key References:

Brugel M, Link TM, Rummeny EJ, Lange P, Theisen J, Dobritz M. Assessment of vascular invasion in pancreatic head cancer with multislice spiral CT: value of multiplanar reconstructions. Eur Radiol 2004; 14(7):1188-95.

Carbone LD, Tylavsky FA, Cauley JA, Harris TB, Lang TF, Bauer DC, Barrow KD, Kritchevsky SB. Association between bone mineral density and the use of nonsteroidal anti-inflammatory drugs and aspirin: impact of cyclooxygenase selectivity. J Bone Miner Res 2003; 18:1795-802.

David-Vauday E, Ghosh S, Ries M, Majumdar S. T2 relaxation time measurements in osteo-arthritis. Magn Res Imag 2004; 22:673-82.

Dunn T, Lu Y, Jin H, Ries M, Majumdar S. MR quantification of cartilage T2 variation with severity of osteoarthritis in the knee. Radiology 2004; 232, 592-8.

Eckstein F, Fischbeck M, Kuhn V, Link TM, Priemel M, Lochmuller EM. Determinants and heterogeneity of mechanical competence throughout the thoracolumbar spine of elderly women and men. Bone 2004; 35(2):364-74.

Eckstein F, Wunderer C, Boehm H, Kuhn V, Priemel M, Link TM, Lochmuller EM. Reproducibility and side differences of mechanical tests for determining the structural strength of the proximal femur. J Bone Miner Res 2004; 19(3):379-85.

Gamio-Caraballido J, Belonghi S, Majumdar S. Normalized cuts in 3D for spinal MRI segmentation. IEEE Trans Med Imaging 2004; 23(1):36-44.

Hudelmaier M, Kuhn V, Lochmuller EM, Well H, Priemel M, Link TM, Eckstein F. Can geometry-based parameters from pQCT and material parameters from quantitative ultrasound (QUS) improve the prediction of radial bone strength over that by bone mass (DXA)? Osteoporos Int 2004; 15(5):375-81.

Lang T, LeBlanc A, Evans H, Lu Y, Genant H, Yu A. Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight, J Bone Miner Res 2004; 19(6):1006-12.

Lewiecki EM, Watts NB, McClung MR, Petak SM, Bachrach LK, Shepherd JA, Downs RW. Official positions of the international society for clinical densitometry. J Clin Endocrinol Metab 2004; 89(8):3651-5.

Lindsey CT, Narasimhan A, Adolfo JM, Jin H, Steinbach LS, Link T, Ries M, Majumdar S. Magnetic resonance evaluation of the interrelationship between articular cartilage and trabecular bone of the osteoarthritic knee. Osteoarthritis Cartilage 2004; 12(2):86-96.

Link TM, Bauer J, Kollstedt A, Stumpf I, Hudelmaier M, Settles M, Majumdar S, Lochmüller EM, Eckstein F. Trabecular bone structure of the distal radius, the calcaneus and the spine – Which site predicts fracture status of the spine best? Invest Radiol 2004; 39:487-97,

Link TM, Koppers BB, Licht T, Bauer J, Lu Y, Rummeny EJ. In vitro and in vivo spiral CT to determine bone mineral density: initial experience in patients at risk for osteoporosis. Radiology 2004; 231:805-11.

Majumdar S, Issever AS, Burghardt A, Lotz J, Arfelli F, Rigon L, Heitner G, Menk R. Diffraction enhanced imaging of articular cartilage and comparison with micro computed tomography of the underlying bone structure. Eur Radiol 2004; 14:1440.

Muehleman C, Majumdar S, et al. X-ray detection of structural orientation in human articular cartilage. Osteoarthritis Cartilage 2004; 12(2):97-105.

Pothuaud L, Newitt D, MacDonald B, Majumdar S. In vivo application of the 3D-Line Skeleton Graph Analysis (LSGA) technique with high-resolution magnetic resonance imaging of trabecular bone structure. Osteoporos Int 2004; 15:411-419.

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Musculoskeletal Radiology
Lynne S. Steinbach, MD, Chief

Research Directions:

• MR-Arthrography at 3 Tesla
• Cartilage imaging, sequence optimization at 3 Tesla
• In vitro and in vivo comparison of cartilage imaging at 1.5T and 3T
• Imaging of osteoarthritis related changes in the longitudinal follow-up
• Contrast enhanced Multislice Spiral CT for assessment of bone density and structure
• Assessment of the symptomatic intervertebral disc using advanced imaging techniques
• MR imaging of mosaicplasty in the longitudinal follow-up
• Applications of wrist MR arthrography
• MRI histopathologic correlation of sacroiliitis in ankylosing spondylitis
• Comparison of 1.5T with 3T MRI for evaluation of smaller joints
• PET for musculoskeletal pathology (multiple myeloma)

Recent Key References:

Anderson SE, Bosshard C, Steinbach LS, Ballmer FT. Calcific tendonitis of the lateral collateral ligament of the knee: a rare pathology rediscovered and visualized with MR imaging. Am J Roentgenol 2003; 181:199-202.

Anderson SE, Steinbach LS, De Monaco D, Bonel HM, Hurtienne Y, Voegeli. "Baby wrist": MRI of an overuse syndrome in mothers. Am J Roentgenol 2004; 182:719-24.

Anderson SE, Weber M, Steinbach LS, Ballmer FT. Shoe rim and shoe buckle pseudotumor of the ankle in elite and professional ice figure skaters and snow boarders: MR imaging findings. Skel Radiol 2004; 33:325-9.

Bauer JS, Issever AS, Fischbeck M, Burghardt A, Eckstein F, Rummeny EJ, Majumdar S, Link TM. Multislice-CT for structure—analysis of trabecular bone: a comparison with micro-CT and biomechanical strength. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr (German) 2004; 176(5):709-18.

Boehm H, Link TM. Bone imaging: Traditional techniques and their interpretation. Curr Osteoporos Rep 2004; 2:41-6.

Boehm H, Raeth C, Newitt D, Majumdar S, Link TM. Local 3D scaling properties - a new structure parameter for the analysis of trabecular bone in high resolution MRI: comparison with BMD in the prediction of biomechanical strength in vitro. Invest Radiol 2003; 38(5):269-80.

Brugel M, Link TM, Rummeny EJ, Lange P, Theisen J, Dobritz M. Assessment of vascular invasion in pancreatic head cancer with multislice spiral CT: value of multiplanar reconstructions. Eur Radiol 2004; 14(7):1188-95.

Daldrup-Link HE, Rudelius M, Oostendorp RA, Settles M, Piontek G, Metz S, Rosenbrock H, Keller U, Heinzmann U, Rummeny EJ, Schlegel J, Link TM. Targeting of hematopoietic progenitor cells with MR contrast agents. Radiology 2003; 228(3):760-7.

Eckstein F, Wunderer C, Boehm H, Kuhn V, Priemel M, Link TM, Lochmuller EM. Reproducibility and side differences of mechanical tests for determining the structural strength of the proximal femur. J Bone Miner Res 2004; 19(3):379-85.

Hudelmaier M, Kuhn V, Lochmuller EM, Well H, Priemel M, Link TM, Eckstein F. Can geometry-based parameters from pQCT and material parameters from quantitative ultrasound (QUS) improve the prediction of radial bone strength over that by bone mass (DXA)? Osteoporos Int 2004; 15(5):375-81.

Lindsey CT, Narasimhan A, Adolfo JM, Jin H, Steinbach LS, Link T, Ries M, Majumdar S. Magnetic resonance evaluation of the interrelationship between articular cartilage and trabecular bone of the osteoarthritic knee. Osteoarthritis Cartilage 2004; 12(2):86-96.

Link, TM. Majumdar S. Current diagnostic techniques in the evaluation of bone architecture. Curr Osteoporos Rep 2004; 2:47-52.

Link TM, Koppers BB, Licht T, Bauer J, Lu Y, Rummeny EJ. In vitro and in vivo spiral CT to determine bone mineral density: initial experience in patients at risk for osteoporosis. Radiology 2004; 231:805-11.

Lochmueller EM, Link TM. Verfahren der quantitativen Knochenmessung in der Vorhersage des individuellen Frakturrisikos - Uebersicht und neue Befunde (Techniques of quantitative bone measurement for predicting individual fracture risk - review and recent findings). Geburtsh Frauenheilk 2004; 64:359-74.

Metz S, Daldrup-Link HE, Richter T, Rath C, Ebert W, Settles M, Rummeny EJ, Link TM, Piert M. Detection and quantification of breast tumor necrosis with MR imaging: value of the necrosis-avid contrast agent Gadophrin-3. Acad Radiol 2003; 10(5):484-90.

Ott K, Fink U, Becker K, Stahl A, Dittler HJ, Busc R, Stein H, Lordick F, Link T, Schwaiger M, Siewert JR, Weber WA. Prediction of response to preoperative chemotherapy in gastric carcinoma by metabolic imaging: results of a prospective trial. J Clin Oncol 2003; 15; 21(24):4604-10.

Rudelius M, Daldrup-Link HE, Heinzmann U, Piontek G, Settles M, Link TM, Schlegel J. Highly efficient paramagnetic labeling of embryonic and neuronal stem cells. Eur J Nucl Med Mol Imaging 2003; 30(7):1038-44.

Stahl A, Ott K, Weber WA, Becker K, Link T, Siewert JR, Schwaiger M, Fink U. FDG PET imaging of locally advanced gastric carcinomas: correlation with endoscopic and histopathological findings. Eur J Nucl Med Mol Imaging 2003; 30(2):288-95.

Steinbach LS. CPPD Crystal Deposition Disease: imaging characteristics. Radiol Clin North Am 2004; 42:185-206.

Tehranzadeh J, Ter-Oganesyan RR, Steinbach LS. Musculoskeletal disorders associated with HIV infection and AIDS: Infectious musculoskeletal conditions. Skeletal Radiol 2004; 33:249-59.

Tehranzadeh J, Ter-Oganesyan RR, Steinbach LS. Musculoskeletal disorders associated with HIV infection and AIDS: Non-infectious musculoskeletal conditions. Skeletal Radiol 2004; 33:311-20.

van Rijn RR, van der Sluis IM, Link TM, Grampp S, Guglielmi G, Imhof H, Glüe C, Adams JE, van Kuijk C. Bone densitometry in children: a critical appraisal. Eur Radiol 2003; 13(4):700-10.

Weber WA, Petersen V, Schmidt B, Tyndale-Hines L, Link T, Peschel C, Schwaiger M. Positron emission tomography in non-small-cell lung cancer: prediction of response to chemotherapy by quantitative assessment of glucose use. J Clin Oncol 2003; 21(14):2651-7.

Weisstein JS, Delgado E, Steinbach L, Hart K, Packman S. Musculoskeletal manifestations of Hurler Syndrome: long-term follow-up after bone marrow transplantation. J Pediatr Orthop 2004; 24:97-101.

Wörtler K, Link TM, Rummeny EJ. Radiologische Diagnostik und Differentialdiagnostik der Osteonekrose. Arthroskopie 2003; 16:15-22.

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Neuroradiology
William P. Dillon, MD, Chief

Research Directions:

• Evaluation of motor pathways in children with motor dysfunction using diffusion tensor magnetic resonance imaging
• Integration of MR and MRS parameters of normal and diseased brain
• Correlations of neurogenetics with MR features of brain malformations and brain tumors
• The use of diffusion tensor imaging to assess early prenatal and post natal brain injury
• Detection of early prenatal and neonatal brain development and prenatal, perinatal, and neonatal brain injuries using advanced imaging techniques
• Assessment of brain injury in infants with congenital heart disease using advanced imaging techniques
• Evaluatiion of the diagnostic potential and clinical usefulness of magnetic resonance imaging of the fetal brain
• Diffusion tensor imaging and fiber tractography to evaluate traumatic brain injury and predict clinical outcome in post-concussive syndrome.
• High angular resolution diffusion imaging to visualize the complex white matter microarchitecture of the human brain.

Recent Key References:

Barkovich AJ, Raybaud CA. Neuroimaging in disorders of cortical development. Neuroimaging Clin N Am 2004; 14(2):231-54, viii.

Chang BS, Piao X, Giannini C, Cascino GD, Scheffer I, Woods CG, Topcu M, Tezcan K, Bodell A, Leventer RJ, Barkovich AJ, Grant PE, Walsh CA. Bilateral generalized polymicrogyria (BGP): a distinct syndrome of cortical malformation. Neurology 2004; 62(10):1722-8.

Enns GM, Barkovich AJ, Van Kuilenburg AB, Manning M, Sanger T, Witt DR, Van Gennip AH. Head imaging abnormalities in dihydropyrimidine dehydrogenase deficiency. J Inherit Metab Dis 2004; 27(4):513-22.

Glastonbury CM, Fischbein NJ, Harnsberger HR, Dillon WP, Kertesz TR. Congenital bifurcation of the intratemporal facial nerve. Am J Neuroradiol 2003; 24(7):1334-7. Erratum in: Am J Neuroradiol 2003; 24(8):1730.

Gleeson JG, Keeler LC, Parisi MA, Marsh SE, Chance PF, Glass IA, Graham Jr JM, Maria BL, Barkovich AJ, Dobyns WB. Molar tooth sign of the midbrain-hindbrain junction: occurrence in multiple distinct syndromes. Am J Med Genet 2004; 125A(2):125-34; discussion 117.

Henry RG, Berman JI, Nagarajan SS, Mukherjee P, Berger MS. Subcortical pathways serving cortical language sites: initial experience with diffusion tensor imaging fiber tracking combined with intraoperative language mapping. NeuroImage 2004; 21:6-622.

Hill MD, Rowley HA, Adler F, Eliasziw M, Furlan A, Higashida RT, Wechsler LR, Roberts HC, Dillon WP, Fischbein NJ, Firszt CM, Schulz GA, Buchan AM; PROACT-II Investigators. Selection of acute ischemic stroke patients for intra-arterial thrombolysis with pro-urokinase by using ASPECTS. Stroke 2003; 34(8):1925-31.

Kim JJ, Fischbein NJ, Lu Y, Pham D, Dillon WP. Regional angiographic grading system for collateral flow: correlation with cerebral infarction in patients with middle cerebral artery occlusion. Stroke 2004; 35(6):1340-4.

Marsh SE, Grattan-Smith P, Pereira J, Barkovich AJ, Gleeson JG. Neuroepithelial cysts in a patient with Joubert syndrome plus renal cysts. J Child Neurol 2004; 19(3):227-31.

Martindale J, Geschwind MD, De Armond S, Young G, Dillon WP, Henry R, Uyehara-Lock JH, Gaskin DA, Miller BL. Sporadic Creutzfeldt-Jakob disease mimicking variant Creutzfeldt-Jakob disease. Arch Neurol 2003; 60(5):767-70.

Maas LC, Mukherjee P, Carballido-Gamio J, Veeraraghavan S, Miller SP, Partridge SC, Henry RG, Barkovich AJ, Vigneron DB. Early laminar organization of the developing human cerebrum demonstrated with diffusion tensor imaging in extremely premature infants. Neuroimage 2004; 22:1134-40.

Mazumdar A, Mukherjee P, Miller JH, Malde H, McKinstry RC. Diffusion-weighted imaging of acute corticospinal tract injury preceding Wallerian degeneration in the maturing human brain. Am J Neuroradiol 2003; 24:1057-66.

Miller SP, Latal B, Clark H, Barnwell A, Glidden D, Barkovich AJ, Ferriero DM, Partridge JC. Clinical signs predict 30-month neurodevelopmental outcome after neonatal encephalopathy. Am J Obstet Gynecol 2004; 190(1):93-9.

Miller SP, McQuillen PS, Vigneron DB, Glidden DV, Barkovich AJ, Ferriero DM, Hamrick SE, Azakie A, Karl TR. Preoperative brain injury in newborns with transposition of the great arteries. Ann Thorac Surg 2004; 77(5):1698-706.

Oh J, Henry RG, Pirzkall A, Lu Y, Li X, Catalaa I, Chang S, Dillon WP, Nelson SJ. Survival analysis in patients with glioblastoma multiforme: predictive value of choline-to-N-acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume. J Magn Reson Imaging 2004; 19(5):546-54.

Partridge SC, Mukherjee P, Henry RG, Miller SP, Berman JI, Jin, H, Lu Y, Glenn OA, Ferriero DM, Barkovich AJ, Vigneron DB. Diffusion tensor imaging: serial quantitation of white matter tract maturity in premature newborns. Neuroimage 2004; 22:1302-14.

Piao X, Hill RS, Bodell A, Chang BS, Basel-Vanagaite L, Straussberg R, Dobyns WB, Qasrawi B, Winter RM, Innes AM, Voit T, Ross ME, Michaud JL, Descarie JC, Barkovich AJ, Walsh CA. G protein-coupled receptor-dependent development of human frontal cortex. Science 2004; 303(5666):2033-6. Comment in: Science 2004; 303(5666):1983-4.

Pirzkall A, Li X, Oh J, Chang S, Berger MS, Larson DA, Verhey LJ, Dillon WP, Nelson SJ. 3D MRSI for resected high-grade gliomas before RT: tumor extent according to metabolic activity in relation to MRI. Int J Radiat Oncol Biol Phys 2004; 59(1):126-37.

Prayer D, Grois N, Prosch H, Gadner H, Barkovich AJ. MR imaging presentation of intracranial disease associated with Langerhans cell histiocytosis. AJNR Am J Neuroradiol 2004; 25(5):880-91.

Quinones-Hinojosa A, Ojemann SG, Sanai N, Dillon WP, Berger MS. Preoperative correlation of intraoperative cortical mapping with magnetic resonance imaging landmarks to predict localization of the Broca area. J Neurosurg 2003; 99(2):311-8.

Takanashi J, Barkovich AJ, Yamaguchi K, Kohno Y. Influenza-associated encephalitis/encephalopathy with a reversible lesion in the splenium of the corpus callosum: a case report and literature review. Am J Neuroradiol 2004; 25(5):798-802.

Wintermark M, Fischbein NJ, Mukherjee P, Yuh EL, Dillon WP. Unilateral putaminal CT, MR, and diffusion abnormalities secondary to nonketotic hyperglycemia in the setting of acute neurologic symptoms mimicking stroke. Am J Neuroradiol 2004; 25(6):975-6.

Wintermark M, Smith WS, Ko NU, Quist M, Schnyder P, Dillon WP. Dynamic perfusion CT: optimizing the temporal resolution and contrast volume for calculation of perfusion CT parameters in stroke patients. Am J Neuroradiol 2004; 25(5):720-9.

Wong ST, Hoo KS Jr, Cao X, Tjandra D, Fu JC, Dillon WP. A neuroinformatics database system for disease-oriented neuroimaging research. Acad Radiol 2004 Mar; 11(3):345-58.

Xu D, Henry RG, Mukherjee P, Carvajal L, Miller SP, Barkovich AJ, Vigneron DB. Single-shot fast spin-echo diffusion tensor imaging of the brain and spine with head and phased array coils at 1.5T and 3.0T. Magn Reson Imaging 2004; 22:751-59.

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Nuclear Medicine
Randall A. Hawkins, MD, PhD, Chief

Research Directions:

• CT/SPECT imaging system: applications in oncology and other disease states
• PET studies of cancer, cardiovascular and neurological diseases
• Feasibility of PET and MRI to characterize myocardial metabolism and flow
• Imaging structure and function in small animals with CT/SPECT

Recent Key References:

Botvinick EH. Scintigraphic blood pool and phase image analysis: the optimal tool for the evaluation of resynchronization therapy. J Nucl Cardiol 2003; 10(4):424-8. Review.

Fong KD, Song HM, Nacamuli RP, Franc BL, et al. Apoptosis in a rodent model of cranial suture fusion: in situ imaging and gene expression analysis. Plast Reconstr Surg 2004; 113(7):2037-47.

Franc BL, Mandl SJ, Siprashvili Z, Wender P, Contag CH. Breaching biological barriers: protein translocation domains as tools for molecular imaging and therapy. Mol Imaging 2003; 2(4):313-23. Review.

Heller GV, Bateman TM, Johnson LL, Cullom SJ, Case JA, Galt JR, Garcia EV, Haddock K, Moutray KL, Poston C, Botvinick EH, et al. Clinical value of attenuation correction in stress-only Tc-99m sestamibi SPECT imaging. J Nucl Cardiol 2004; 11(3):273-81.

Pham KH, Botvinick EH. Increased right ventricular activity: artifact of camera head misalignment. J Nucl Cardiol 2003; 10(5):575-6.

Wang ZJ, Reddy GP, Gotway MB, Higgins CB, Jablons DM, Ramaswamy M, Hawkins RA, Webb WR. Malignant pleural mesothelioma: evaluation with CT, MR imaging, and PET. Radiographics 2004; 24(1):105-19. Review.

Weiss B, Vora A, Huberty J, Hawkins RA, Matthay KK. Secondary myelodysplastic syndrome and leukemia following 131I-metaiodobenzylguanidine therapy for relapsed neuroblastoma. J Pediatr Hematol Oncol 2003; 25(7):543-7.

Research Directions:

• Quantitative use of imaging to measure structural changes within joints in arthritic conditions in large multicenter studies
• Assessment of the use of micro-arthrography involving microCT
• Assessment of the trabecular microstructure of postmenopausal model in rats using microCT
• Development and validation of noninvasive quantitative imaging techniques in the field of musculoskeletal disorders
• Study of metabolic bone disease and orthopedic and rheumatologic disorders using noninvasive quantitative imaging techniques
• Development of methods to examine inflammation and structural alterations within the TMJ using MRI

Recent Key References:

Carano RAD, Lynch JA, Redei J, Ostrowitzki S, Miaux Y, Zåim S, White DL, Peterfy CG, Genant HK. Multispectral analysis of bone lesions in the hands of patients with rheumatoid arthritis. Magn Reson Imaging 2004; 22:505-14.

Grigoryan M, Lynch JA, Fierlinger AL, Guermazi A, Fan B, MacLean DB, MacLean A, Genant HK. Quantitative and qualitative assessment of closed fracture healing using computed tomography and conventional radiography. Acad Radiol 2003; 10(11):1267-73.

Grigorian M, Roemer FW, Mohr A, Genant HK. Imaging in spondyloarthropathies. Curr Rheumatol Rep 2004; 6(2):102-9.

Guermazi A, Roemer, FW, Genant HK. Brodie abscess: another type of chronic posttraumatic osteomyelitis. Eur Radiol 2003; 13(7):1750-2.

Jiang Y, Zhao JJ, Mitlak BH, Wang O, Genant HK, Eriksen EF. Quantitative and qualitative assessment of closed fracture healing using computed tomography and conventional radiography. Acad Radiol 2003; 10(11):1267-73.

Lynch JA, Grigoryan M, Fierlinger A, Guermazi A, Zaim S, MacLean DB, Genant HK. Measurement of changes in trabecular bone at fracture sites using X-ray CT and automated image registration and processing. J Orthop Res 2004; 22(2):362-7.

Meunier PJ, Roux C, Seeman E, Ortolani S, Badurski JE, Spector TD, Cannata J, Balogh A, Lemmel EM, Pors-Nielsen S, Rizzoli R, Genant HK, Reginster JY. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 2004; 350(5):459-68.

Mohr A, Heiss C, Bergmann I, Schrader C, Roemer FW, Lynch JA, Muhle C, Genant HK, Heller M. Value of micro-CT as an investigative tool for osteochondritis dissecans. Acta Radiol 2003; 44(5):532-7.

Ostrowitzki S, Redei J, Lynch JA, Carano RA, Zaim S, Miaux Y, Genant HK. Use of multispectral magnetic resonance imaging analysis to quantify erosive changes in the hands of patients with rheumatoid arthritis: short-term and long-term longitudinal studies. Arthritis Rheum 2004; 50(3):716-24.

Paulus HE, Di Primeo D, Sharp JT, Genant HK, Weissman BN, Weisman MH, Sanda M. Long-Term Etodolac Study Investigators. Patient retention and hand-wrist radiograph progression of rheumatoid arthritis during a 3-year prospective study that prohibited disease modifying antirheumatic drugs. J Rheumatol 2004; 31(3):470-81.

Peterfy CG, Guermazi A, Zaim S, Tirman PF, Miaux Y, White D, Kothari M, Lu Y, Fye K, Zhao S, Genant HK. Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis. Osteoarthritis Cartilage 2004; 12(3):177-90.

Prevrhal S, Meta M, Genant HK; Two new regions of interest to evaluate separately cortical and trabecular BMD in the proximal femur using DXA. Osteoporos Int 2004; 15(1):12-9.

Taouli B, Zaim S, Peterfy CG, Lynch JA, Stork A, Guermazi A, Fan B, Fye KH, Genant HK. Rheumatoid arthritis of the hand and wrist: comparison of three imaging techniques. Am J Roentgenol 2004; 182(4):937-43.

Uusi-Rasi K, Kannus P, Cheng S, Sievanen H, Pasanen M, Heinonen A, Nenonen A, Halleen J, Fuerst T, Genant H, Vuori I. Effect of alendronate and exercise on bone and physical performance of postmenopausal women: a randomized controlled trial. Bone 2003; 33(1):132-43.

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Pediatric Radiology
Charles A. Gooding, MD, Chief

Research Directions:

• Application of advances in imaging technologies to investigation of pediatric disease
• Labeling of various cell types with targeted contrast agents and in vivo tracking of these cells with magnetic resonance imaging
• Study of differences between umbilical cord blood derived progenitor cells and peripheral blood derived progenitor cells
• Potential of bifunctional-fluorescent and paramagnetic-contrast agents to trace intravenously injected human hematopoietic progenitor cells in a murine xenotransplant model using optical and MR imaging

Recent Key References:

Daldrup-Link HE, Okuhata Y, Wolfe A, Srivastav S, Oie S, Ferrara N, Cohen RL, Shames DM, Brasch R. Decrease in tumor apparent permeability-surface area product to a MRI macromolecular contrast medium following angiogenesis inhibition with correlations to cytotoxic drug accumulation. Microcirculation 2004; 11:387-396.

Daldrup-Link HE, Rudelius M, Oostendorp RAJ, Settles M, Piontek G, Metz S, Heinzmann U, Rummeny EJ, Schlegel J, Link TM. Targeting of hematopoietic progenitor cells with MR contrast agents. Radiology 2003; 228:760-7.

Metz S, Daldrup-Link HE, Richter T, Rath C, Ebert W, Settles M, Rummeney EJ, Link TM, Piert M. Detection and quantification of breast tumor necrosis by MRI: value of the necrosis avid contrast agent gadophrin-3. Acad Radiol 2003; 10:484-490.

Rudelius M, Daldrup-Link HE, Heinzmann U, Piontek G, Settles M, Link TM, Schlegel J: Highly efficient paramagnetic labelling of embryonic and neuronal stem cells. Eur J Nucl Med Mol Imaging 2003; 7:1038-1044.

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Physics Research Laboratory
Bruce Hasegawa, PhD, Director

Research Directions:

• Development of combined x-ray/radionuclide imaging systems for diagnosis of cancer and cardiovascular disease
• Development of high-resolution radionuclide and x-ray systems for biological research

Recent Key References:

Barber WC, Iwata K, Hasegawa BH, Bennett PR, Cirignano LJ, Shah KS. A single CdZnTe detector for simultaneous CT/SPECT imaging. Nucl Instrum Meth Phys Res 2003; 505:595-8.

Hasegawa BH, Barber WC, Funk T, Hwang AB, Sakdinawat AE, Taylor C, Sun M, Seo Y. Implementation and applications of dual-modality imaging. Nucl Instrum Meth 2004; 525(1-2):236-41.

Kinahan PE, Hasegawa BH, Beyer T. X-ray-based attenuation correction for positron emission tomography/computed tomography scanners. Semin Nucl Med 2003; 33:166-79.

Pivovaroff MJ, Barber WB, Christensen FE, Craig WW, Decker T, Epstein M, Funk T, Hasegawa BH, Hailey CJ, Hill R, Jernigan JG, Taylor C, Ziock K. Small animal radionuclide imaging with focusing gamma-ray optics. In Medical Applications of Penetrating Radiation III. Edited by HB Barber, H Roehrig. Proc of SPIE 2004; 5199:147-61.

Wu MC, Gao DW, Sievers RC, Lee RJ, Hasegawa BH, Dae MW. Pinhole single-photon emission computed tomography for myocardial perfusion imaging of mice. J Amer College Cardiol 2003; 42:576-82.

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Radiological Outcomes Research Lab
Rebecca Smith-Bindman, MD, Director

Research Directions:

• Use of prenatal ultrasound for diagnosis of birth defects, chromosomal abnormalities, and reproductive outcomes
• Physician predictors of accuracy in the areas of ultrasound and mammography
• Utilization of screening mammography in the U.S., by age, race, SES
• Racial disparities in breast cancer mortality
• The impact of mammography on patient outcomes in elderly women
• Improving communication of radiology results to referring clinicians
• Methods to improve the accuracy of screening mammography

Recent Key References:

Benn PA, Egan JF, Fang M, Smith-Bindman R. Changes in the utilization of prenatal diagnosis. Obstet Gynecol 2004; 103(6):1255-60.

Elad Z, Shepherd J, Smith-Bindman R, Kerlikowske K. Mammographic breast density and family history of breast cancer. J Natl Cancer Inst 2003; 95(7):556-8.

Kerlikowske K, Smith-Bindman R, Barclay J, Ling BM, Grady D. Evaluation of abnormal mammography examinations and breast abnormalities. Ann Intern Med 2003; 139(4):274-84.

Kerlikowske K, Smith-Bindman R, Sickles EA. Short-interval follow-up mammography: are we doing the right thing? J Natl Cancer Inst 2003; 19;95(6):418-9.

Smith-Bindman R, Chu P, Miglioretti D, Ballard-Barbash R, Blanks R, Lee N, Wallis M, Sickles E, Kerlkowske K. Comparison of screening mammography in the United States and the United Kingdom. JAMA 2003; 290(16):2129-37.

Smith-Bindman R, Chu B, Waters J, Mutton D, Alberman E. Down Syndrome screening methods and birth outcomes in England and Wales, 1989-1999. Am J Obst Gynecol 2003; 189(4):980-5

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San Francisco General Hospital
Michael B. Gotway, MD, Acting Chief

Research Directions:

• Diagnosis of small bowel disease with CT of the abdomen and pelvis versus capsule (video) endoscopy
• Staging of pancreatitis by CT and comparison to clinical criteria such as Apache, Ranson
• Effect of T1-shortening on T2-weighted sequences following gadolinium injection in patients with focal liver lesions
• Utility of helical CT pulmonary angiography for predicting outcomes in patients with acute pulmonary embolism
• Helical CT esophagography: a new method for diagnosis esophageal perforation/rupture in the seriously ill or injured patient
• Utility of somatostatin receptor binding agents for the detection and staging of lung carcinoma
• Imaging findings in the following areas:
  1. Primary lymphoepithelial carcinoma of the lung
  2. Inflammatory myofibroblastic tumor of the thorax
  3. Pulmonary artery sarcoma
  4. Traumatic brain injury
  5. Takayasu arteritis
  6. Pulmonary microsporidiosis

Recent Key References:

Chang SD, Thoeni RF. Castleman's disease presenting as an adnexal mass: ultrasound, CT and MRI features. Br J Radiol 2004; 77(914):161-3.

Fadoo F, Ruiz DE, Dawn SK, Webb WR, Gotway MB. Helical CT esophagography for the evaluation of suspected esophageal perforation. Am J Roentgenol 2004; 182(5):1177-9.

Harris HW, Barcia A, Schell MT, Thoeni RF, Schecter WP. Necrotizing pancreatitis: a surgical approach independent of documented infection. HPB Surg 2004; 6:1-8.

Hastings GS, Marder SR. Imaging and endovascular intervention for thoracic vascular trauma. Semin Interv Radiol 2003; 20:97-110.

Murthy R, Hastings GS, Richard HM, Levitin A. Angiography and endovascular intervention for vascular trauma to the extremities. Semin Interv Radiol 2003; 20:81-8.

Susac JO, Murtagh FR, Egan RA, Berger JR, Bakshi R, Lincoff N, Gean AD, et al. MRI findings in Susac's syndrome. Neurology 2003; 61(12):1783-7. Review.

Trowbridge RL, Araoz PA, Gotway MB, Bailey RA, Auerbach AA. The Effect of helical computed tomography on diagnostic and treatment strategies in patients with suspected pulmonary embolism. Am J Med 2004; 116(2):84-90.

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Ultrasound
Ruth B. Goldstein, MD, Chief

Research Directions:

• Prenatal diagnosis of CNS anomalies with ultrasound and MRI
• Evaluation of ultrasonic contrast agents in the liver, and both native and transplanted kidneys
• Characterization of vascular connections in twin-twin transfusion syndrome with color and spectral Doppler sonography
• Prospective, randomized trial of repair of fetal myelomeningocele
• Prospective, randomized trial for selective ablation of connecting vessels in twin transfusion syndrome

Recent Key References:

Coakley FV, Glenn OA, Qayyum A, Barkovich AJ, Goldstein R, Filly RA. Fetal MRI: a developing technique for the developing patient. Am J Roentgenol 2004; 182:243-52.

Harrison MR, Keller RL, Hawgood SB, Kitterman JA, Sandberg PL, Farmer DL, Lee H, Filly RA, Farrell JA, Albanese CT. A randomized trial of fetoscopic tracheal occlusion for severe fetal congenital diaphragmatic hernia. N Eng J Med 2003; 349(20):1916-24.

Harrison MR, Sydorak RM, Farrell JA, Kitterman JA, Filly RA, Albanese, CT. Fetoscopic temporary tracheal occlusion for congenital diaphragmatic hernia: Prelude to a randomized, controlled trial. J Pediatr Surg 2003; 38(7):1012-20.

Moes MJ, Filly RA. The neonatal diaphragmatic crura are hypertrophied; a necessary preparation for the first breath? J Ultrasound Med 2003; 22:715-18.

Winn VD, Sonson J, Filly RA. Echogenic intracardiac focus: potential for misdiagnosis. J Ultrasound Med 2003; 22:1207-14.

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Veterans Affairs Medical Center

Research Directions:

Diagnostic Radiology – Judy Yee, MD, Chief

View virtual colonoscopy demo.

• Vascular ultrasound waveform analysis
• Contrast-enhanced CT colonography
• Fecal tagging using barium for CT colonography
• Efficacy and safety of Visipaque (Iodixanol) injection for use in intravenous contrast-enhanced CT angiography of abdominal vessels
• Prospective comparison of colonic imaging tests
• Image checker CAD for virtual colonoscopy

Magnetic Resonance Unit – Michael W. Weiner, MD, Director

• Early detection and diagnosis of dementia
• Effects of HIV and alcohol on the brain
• Effects of gulf war illness on basal ganglia
• MRI and MRSI of ALS, Parkinson's disease, epilepsy
• Effects of post traumatic stress disorder on the brain

Vascular Imaging Research Center – David A. Saloner, PhD, Director

• Conduct of a multi-center study to measure changes in atherosclerosis morphology over time
• Development of improved methods for flow quantitation in aneurysms
• Combined use of imaging and simulation in determining durability of stent-graft devices for treatment of aortic disease
• Evaluation of the use of computational methods for determining whether changes in aneurysm geometry correlate with hemodynamic effects

Recent Key References:

Diagnostic Radiology

Abraham C, Reilly L, Schneider D, Dwyer S, Sawhney R, Messina L, Chuter T. A modular multi-branched system for endovascular repair of bilateral common iliac artery aneurysms. J Endovasc Ther 2003; 10(20):203-7.

Ferruci J, Barish M, Choi R, Dachman A, Fenlon H, Glick S, Laghi A, Macari M, Morrin M, Paulson E, Pickhardt PJ, Soto J, Yee J, Zalis M. Working Group on Virtual Colonoscopy. Virtual Colonoscopy. JAMA 2004; 292(4):431-2.

Glastonbury CM, Kennedy AM. Images in clinical medicine: a fetus with hypogenesis of the corpus callosum. N Engl J Med 2003; 349:e6.

Gooding GAW, Kane RA, Townsend RR, Frates MC, Mellstrup JW, Reading CC. Collaborative Subcommittee of ACR and AIUM. AIUM practice guideline for the performance of a thyroid and parathyroid ultrasound examination. J Ultrasound Med 2003; 22:1126-30.

Gooding GAW, Kane RA, Townsend RR, Frates MC, Mellstrup JW, Reading CC. Collaborative Subcommittee of ACR and AIUM. ACR practice guideline for the performance of a thyroid and parathyroid ultrasound examination. American College of Radiology Practice Guidelines and Technical Standards 2003; 603-6.

Johnson CD, Toledano AY, Herman BA, Dachman AH, McFarland EG, Balfe D, Barish M, Brink J, Ernst R, Fletcher JG, Halvorsen R, Hopper KD, Koehler RE, Lu D, Macari M, MacCarty R, Miller F, Morrin M, Paulson E, Yee J, Zalis M. CT colonography: performance evaluation in a retrospective multicenter setting (American College of Radiology Imaging Network Study 6656) Gastroenterology 2003; 125:688-95.

Kerlan R, LaBerge J, Wilson M, Gordon R, Kirkwood K, Sawhney R. Massive hemorrhage from portal vein disruption. J Vasc Interv Radiol 2003; 14:797-802.

Kirshenbaum SB, Hirky AE, Correale J, Goldstein RB, Johnson MO, Rotheram-Borus MJ, Ehrhardt AA. “Throwing the dice": pregnancy decision-making among HIV-positive women in four U.S. cities. Perspect Sex Reprod Health 2004; 36(3):106-13.

Mani A, Napel S, Paik D, Jeffrey RB, Yee J, Olcott EO, Prokesch R, Davila M, Schraedley-Desmond P, Beaulieu CF. CT colongraphy: feasibility of computer-aided polyp detection in a "First Reader" paradigm. J Comput Assist Tomogr. 2004; 28:318-26.

Oh KY, Gilfeather ME, Kennedy AM, Glastonbury C, Green D, Brant W, Yoon H-C. Limited abdominal MRI in the evaluation of acute right upper quadrant pain. Abdom Imaging 2003; 28:643-51.

Paik DS, Beaulieu CF, Rubin GD, Acar B, Jeffrey RB, Yee J, Dey J, Napel S. Surface normal overlap: a computer aided detection algorithm with application to colonic polyps and lung nodules in helical CT. IEEE Trans Med Imaging 2004; 23:661-75.

Reeders JWAJ, Yee J, Gore RM, Miller FH, Megibow AJ. Gastrointestinal infections in the immuno-compromised (AIDS) patient. Eur Radiol 2004; 14:84-102.

Weatherburn GC, Ridout D, Strickland NH, Robins P, Glastonbury CM, Curati W, Harvey C, Shadbolt C. A comparison of conventional film, CR hard copy and PACS soft copy images of the chest: analyses of ROC curves and inter-observer agreement. Eur J Radiol 2003; 47:206-14.

Yee J. Screening CT colonography. Radiol Clin N Am 2004; 42(4):757-66.

Yee J, Galdino G, Urban J, Sawhney R. CT angiography of aortic endovascular stent grafts. Crit Rev Comput Tomogr 2004; 45:17-65.

Yee J, Wall SD, McQuaid KR. By-patient performance characteristics of CT colonography: importance of polyp size threshold data [letter]. Radiology 2003; 229:291-3.

Magnetic Resonance Unit

Blumenfeld H, McNally KA, Vanderhill SD, Paige AL, Chung R, Davis K, Norden AD, Stokking R, Studholme C, Novotny EJ, Jr, Zubal IG, Spencer SS. Positive and negative network correlations in temporal lobe epilepsy. Cereb Cortex 2004; 14(8):892-902.

Blumenfeld H, Westerveld M, Ostroff RB, Vanderhill SD, Freeman J, Necochea A, Uranga P, Tanhehco T, Smith A, Seibyl JP, Stokking R, Studholme C, Spencer SS, Zubal IG. Selective frontal, parietal, and temporal networks in generalized seizures. Neuroimage 2003; 19(4):1556-66.

Boxer A, Kramer JH, Schuff N, Du AT, Weiner MW. Focal right inferotemporal atrophy in AD with disproportionate visual constructive impairment. Neurology 2003; 61(11):1485-91.

Chao LL, Lindgren JA, Flenniken DL, Weiner MW; ERP evidence of impaired central nervous system function in virally suppressed HIV patients on antiretroviral therapy. Clin Neurophysiol 2004; 115:1583-91.

Chao LL, Meyerhoff DJ, Cardenas VA, Rothlind JC, Weiner MW. Abnormal CNV in chronic heavy drinkers. Clin Neurophysiol 2003; 114(11):2081-95.

Chao LL, Meyerhoff DJ, Cardenas-Nicolson VA, Rothlind JC, Weiner MW. Abnormal contingent negative variation in HIV patients receiving antiretroviral therapy. Neuroreport 2003; 14(16):2111-15.

Chao LL, Meyerhoff DJ, Lindgren JA, Weiner MW. The effects of chronic alcohol use on implicit memory and decision-making abilities. Clin Neurophysiol 2003; 114(11):2081-95.

DeCarli C, Mungas D, Harvey D, Reed B, Weiner M, Chui H, Jagust W. Memory impairment, but not cerebrovascular disease predicts progression of MCI to dementia. Neurology 2004; 63(2):220-7.

Du AT, Schuff N, Kramer JH, Ganzer S, Zhu XP, Jagust WJ, Miller BL, Reed BR, Mungas D, Yaffe K, Chui HC, Weiner MW. Higher atrophy rate of entorhinal cortex than hippocampus in AD. Neurology 2004; 62:422-7.

Ebel A, Govindaraju V, Maudsley AA. Comparison of inversion recovery preparation schemes for lipid suppression in 1H MRSI of human brain. Magn Reson Med 2003; 49(5):903-8.

Ebel A, Maudsley AA: Improved spectral quality for 3D MR spectroscopic imaging using a high spatial resolution acquisition strategy. Magn Reson Imaging 2003; 21(2):113-20.

Gorno-Tempini ML, Dronkers NF, Rankin KP, Ogar JM, Phengrasamy L, Rosen HJ, Johnson JK, Weiner MW, Miller BL. Cognition and anatomy in three variants of primary progressive aphasia. Ann Neurol 2004; 55(3):335-6.

Govindaraju V, Gauger GE, Manley GT, Ebel A, Meeker M, Maudsley AA. Volumetric proton spectroscopic imaging of mild traumatic brain injury. Am J Neuroradiol 2004; 25(5):730-7.

Liu W, Miller BL, Kramer JH, Rankin K, Wyss-Coray C, Gearhart R, Phengrasamy L, Weiner M, Rosen HJ. Behavioral disorders in the frontal and temporal variants of frontotemporal dementia. Neurology 2004; 62(5):742-8.

Meyerhoff DJ, Blumenfeld R, Truran D, Lindgren J, Flenniken D, Cardenas VA, Chao L, Rothlind J, Studholme C, Weiner MW. Effects of heavy drinking, binge drinking, and family history of alcoholism on regional brain metabolites. Alcoholism Clin Exp Res 2004; 28(4):650-61.

Mueller SG, Laxer KD, Cashdollar N, Flenniken DL, Matson GB, Weiner MW. Identification of abnormal neuronal metabolism outside the seizure focus in temporal lobe epilepsy. Epilepsia 2004; 45(4):355-66.

Mueller SG, Weber OM, Duc CO, Meier D, Russ W, Boesiger P, Wieser HG. Effects of vigabatrin on brain GABA+/Cr signals in focus-distant and focus-near brain regions monitored by 1H-NMR spectroscopy. Eur J Neurol 2003; 10(1):45-52.

Neylan TC, Lenoci M, Rothlind J, Metzer TJ, Schuff N, Du AT, Franklin K, Weiss DS, Weiner MW, Marmar CR. Attention, learning and memory in posttraumatic stress disorder. J Trauma Stress 2004; 17(1):41-6.

Neylan TC, Schuff N, Lenoci M, Yehuda R, Weiner MW, Marmar CR. Cortisol levels are positively correlated with hippocampal N-acetylaspartate. Biol Psychiatry 2003; 54(10):1118-21.

Rankin KP, Rosen HJ, Kramer JH, Schauer GF, Weiner MW, Schuff N, Miller BL. Right and left medial orbitofrontal volumes show an opposite relationship to agreeableness in FTD. Dement Geriatr Cogn Disord 2004; 17(4):328-32.

Schuff N, Capizzano AA, Du AT, Amend DL, O’Neill J, Norman D, Jagust WJ, Chui HC, Kramer JH, Miller BL, Yaffe K, Reed B, Weiner MW. Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and AD. Neurology 2003; 61(3):358-64.

Studholme C, Cardenas V, Blumenfeld R, Schuff N, Rosen HJ, Miller B, Weiner W. Deformation tensor morphometry of semantic dementia with quantitative validation, Neuroimage 2004; 21(4):1387-98.

Studholme C, Cardenas V, Maudsley A, Weiner M. An intensity consistent filtering approach to the analysis of deformation tensor derived maps of brain shape. Neuroimage 2003; 19(4);1638-49.

Studholme C, Cardenas V, Song E, Ezekiel F, Maudsley A, Weiner M. Accurate template-based correction of brain MRI intensity distortion with application to dementia and aging. IEEE Trans Med Imaging 2004; 23(1):99-110.

Wang J, Licht DJ, Jahng GH, Liu CS, Rubin JT, Haselgrove J, Zimmerman RA, Detre JA. Pediatric perfusion imaging using pulsed arterial spin labeling. J Magn Reson Imaging 2003; 18(4):404-13.

Weiner MW, Albert MS, DeCarli CS, de Leon M, Fox NC, Jack CR, Jr, Jagust WJ, Reiman EM, Scheltens P, Small GW, Soininen H, Wahlund L-O. Proceedings and abstracts second meeting of the Alzheimer’s Imaging Consortium Stockholm Fairgrounds, Stockholm, Sweden, July 20, 2002. Neurobiol Aging 2004; 25:239-270.

Wilhelmsen KC, Forman MS, Rose HJ, Alving LI, Goldman J, Feiger J, Lee JV, Segall SK, Kramer JH, Lomen-Hoerth C, Rankin KP, Johnson J, Feiler HS, Weiner MW, Lee VM, Trojanowski JQ, Miller BL. 17 q-linked frontotemporal dementia-amyotrophic lateral sclerosis without Tau mutations with Tau and A-Synuclein inclusions. Arch Neurol 2004; 61:398-406.

Yue N J, Knisely J P, Studholme C, Chen Z, Bond JE, Nath R. A technique to re-establish dose distributions for previously treated brain cancer patients in external beam radiotherapy. Med Dosim 2004; 29(1):31-41.

Zhu X, Du A, Jahng GH, Soher B, Maudsley A, Weiner MW, Schuff N. Magnetic resonance spectroscopic imaging reconstruction with deformable shape-intensity models. Magn Reson Med 2003; 50(3):474-82.

Vascular Imaging Research Center

Jou LD, Rapp J, Saloner D. Transport of Contrast agents in contrast-enhanced magnetic resonance angiography. J Magn Reson Imaging 2004; 22:495-504.

Jou LD, Quick CM, Young WL, Lawton MT, Higashida R, Martin A, Saloner D. Computation approach to quantifying hemodynamic forces in giant cerebral aneurysms. Am J Neuroradiol; 2003; 24:1804-10.

Rapp JH, Saloner D. Current status of carotid imaging by MRA. Cardiovasc Surg 2003; 11:445-7.

Rapp JH, Pan XM, Yu B, Swanson R, Higashida R, Simpson P, Saloner D. Cerebral ischemia and infarction from atheroemboli. Stroke 2003; 64A:197-206.

Townsend TC, Saloner D, Pan XM, Rapp JH. Contrast material-enhanced MRA overestimates severity of carotid stenosis, compared with 3D time-of-flight MRA. J Vasc Surg 2003; 38:36-40.

Yu B, Pan XM, Saloner D, Troyer A, Rapp JH. Double-lumen carotid plaque: a morbid configuration. J Vasc Surg 2003; 37:1314-7.