UCSF Physics Research Laboratory
Bruce Hasegawa, PhD, Director, 415/353-9472

This laboratory pursues the development and application of imaging techniques for the assessment of cancer and heart disease using dual-modality imaging. The laboratory also trains graduate students and postdoctoral fellows in medical imaging. Laboratory resources include an experimental emission-transmission CT system, two high-resolution dual-modality imaging systems for biological research, electronics and detector laboratory, and radiopharmaceutical handling/storage facilities. Current work is focused on development of instrumentation and algorithms for biological research; development of a high-resolution gamma-ray focusing lens; and development of dual-modality imaging for diagnosis of cancer and heart disease.

(See article "Dual-Modality Imaging with SPECT/CT")

Research Directions:

• Development of combined x-ray/radionuclide imaging systems for diagnosis of cancer and cardiovascular disease
• Development of high-resolution radionuclide and x-ray systems for biological research

Recent Key References:

Seo Y, Franc BL, Hawkins RA, Wong KH, Hasegawa BH. Progress in SPECT/CT imaging of prostate cancer. Technol Cancer Res Treat. 2006 Aug;5(4):329-36.

Wu MC, Gao DW, Sievers RE, Lee RJ, Hasegawa BH, Dae MW. Pinhole single-photon emission computed tomography for myocardial perfusion imaging of mice. J Am Coll Cardiol. 2003 Aug 6;42(3):576-82.

Hasegawa BH, Wong KH, Iwata K, Barber WC, Hwang AB, Sakdinawat AE, Ramaswamy M, Price DC, Hawkins RA. Dual-modality imaging of cancer with SPECT/CT. Technol Cancer Res Treat. 2002 Dec;1(6):449-58.

Hasegawa BH, Iwata K, Wong KH, Wu MC, Da Silva AJ, Tang HR, Barber WC, Hwang AH, Sakdinawat AE. Dual-modality imaging of function and physiology. Acad Radiol. 2002 Nov;9(11):1305-21. Review.

Da Silva AJ, Tang HR, Wong KH, Wu MC, Dae MW, Hasegawa BH. Absolute quantification of regional myocardial uptake of 99mTc-sestamibi with SPECT: experimental validation in a porcine model. J Nucl Med. 2001 May;42(5):772-9.

Tang HR, Da Silva AJ, Matthay KK, Price DC, Huberty JP, Hawkins RA, Hasegawa BH. Neuroblastoma imaging using a combined CT scanner-scintillation camera and 131I-MIBG. J Nucl Med. 2001 Feb;42(2):237-47.